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  • in terms of devices in general is trying to say that before this outbreak, it was fairly backwater area of virus research.

  • There are human corona viruses that cause colds.

  • They've been around for a very long time, but they're not particularly serious diseases.

  • But now the lab's a homing scientists here at Bristol University of some of the few who were growing the human Corona virus involved in this outbreak, the name of the viruses solves cov to working out how the virus interacts with the cells in the body and then how the cells in the body respond.

  • The virus gets its name from the crown like spikes that adorn its membrane corona being Spanish for crown.

  • The men brain contains the virus's genome.

  • In other words, it's genetic data wrapped up in virus proteins.

  • When the virus attached itself to a human cell, it starts to tell it how to make its own virus proteins, which not only helps the virus to thrive inside our bodies but can confound the human immune system.

  • Scientists hope to decipher the genome messages the virus is sending unlearn what the resulting proteins actually do.

  • You really need to start to dissect the virus on many different levels, dissect our immune response and so on and so forth.

  • And so the work we're doing here are some of the work we're doing here is gonna be starting underpinned that Which is the sort of say this, what the vice does This gets into a cell, said the things that makes these things.

  • It does to a sound these parts of the cells that it disables and makes a mess off in order to make its own life easier on that process begins here.

  • Really, Knowing what the virus does when it gets into a cell will help scientists around the world understand what they could do to kill or prevent the growth of the virus.

  • The Bristol team are also making copies of the virus to help test vaccines drugs on other diagnostic tools on its homeless work.

  • We can't actually go into the lab where the virus is air being made or identify where it's located.

  • Live virus itself has handled at what's called containment level three because this is a virus that's sort of spread by air souls.

  • We have even another degree of safety that we have a sealed cabinet on.

  • We work with the virus in that cabinet using a glove system.

  • So the virus you can't get out of that cabinet, and then it's another contained room on their nuts in another contained the bar tree.

  • Saul's COV two isn't the first Corona virus to cause serious illnesses and humans.

  • Back in the early two thousands, the original SARS outbreak killed over 700 people worldwide.

  • One in 10 died from the disease, but it didn't spread very well.

  • A decade later, hundreds died of the MERS virus.

  • It was faithful in about 1/3 but again it didn't spread very well.

  • This new Corona virus seems to spread well but is lethal in a relatively small percentage of people.

  • You could say this virus has kind of hit something of a sweet spot in terms off, being able to cause disease in humans relatively efficiently.

  • But not such a dramatic, debilitating disease very quickly, which means that the people that are infected are able to make more contacts with more of the people into the virus, spreads further.

  • But studying the other human corona viruses, murders and Sal's wall has helped scientists understand what might work to help fight it.

  • We know that it's actually very closely related to existing Corona viruses, so that means that people have already characterized a lot of things.

  • During the size of the first cells outbreak, They looked at trialing vaccines.

  • They looked at potential antiviral medicines.

  • They looked at diagnostics, and already some of these are being used on the SARS coronavirus, too.

  • The first clinical trial of an experimental vaccine is about to be tested on 45 adults in Seattle.

  • The study will test the safety of various doses of the vaccine and, if it produces an immune response in the response to the outbreak.

  • What what you're hoping for a vaccine or may be drugs.

  • If we're very lucky on, hopefully those will pan out and they will find out very quickly.

  • But there are no guarantees it will be effective, and there were still holds in our knowledge.

  • What we don't know, however, is the transmission seems to be different to other human pathogenic corona viruses.

  • We know it's spreading more rapidly, doesn't seem to be as contained as we were able to with South Korean virus.

  • We don't know for any of these viruses really a lot about their pathogenesis.

  • Well, how they how they really cause disease, how they interact with the host to cause acute respiratory syndrome.

in terms of devices in general is trying to say that before this outbreak, it was fairly backwater area of virus research.

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