Placeholder Image

Subtitles section Play video

  • I think the thing that's amazing about science

  • and about biology for me is that there's always more

  • to be discovered, and every time we feel like we've figured

  • something out, it seems to open up several more questions.

  • (gentle percussive music)

  • Scientists have appreciated for a long time

  • that once we understood the DNA sequence in cells,

  • if we had a tool that would allow easy manipulation

  • of that sequence, that that would be

  • a very powerful kind of technology.

  • (gentle percussive music)

  • CRISPR is a technology for changing the sequence

  • of DNA in cells in a precise fashion to correct mutations

  • that might otherwise cause disease.

  • It's going to enable a lot of science to be done

  • that was impossible to do in the past.

  • So the way the CRISPR technology works is

  • by the action of a protein called Cas9 that functions

  • like a molecular scalpel for DNA.

  • The CRISPR Cas9 system has an amazing ability

  • to recognize a particular DNA sequence in a cell that may be

  • malfunctioning, and then disable it by cutting the DNA.

  • We call this gene editing, and we can use it

  • to disable or repair a mutated part of the gene,

  • which may be causing disease.

  • For Cas9 to find the malfunctioning DNA,

  • we attach it to an RNA sequence

  • that matches the DNA sequence we want to edit.

  • Then we put this RNA Cas9 combination into the cell.

  • It finds the mutant DNA and uses the chemical reaction

  • to cut the DNA strand right at the spot

  • where it's malfunctioning.

  • After that, we can sometimes insert the correct version

  • of the gene for the cell to work properly again.

  • It's a very exciting technology that's going to do

  • a lot of good in human society and for human health.

  • It stretches from human therapeutics

  • to agricultural applications to thinking about

  • how do we make better biofuels.

  • These would be incredible outcomes, I think,

  • of using this kind of technology in the future.

  • (gentle percussive music)

I think the thing that's amazing about science

Subtitles and vocabulary

Click the word to look it up Click the word to find further inforamtion about it