B2 High-Intermediate US 50 Folder Collection
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I think the thing that's amazing about science
and about biology for me is that there's always more
to be discovered, and every time we feel like we've figured
something out, it seems to open up several more questions.
(gentle percussive music)
Scientists have appreciated for a long time
that once we understood the DNA sequence in cells,
if we had a tool that would allow easy manipulation
of that sequence, that that would be
a very powerful kind of technology.
(gentle percussive music)
CRISPR is a technology for changing the sequence
of DNA in cells in a precise fashion to correct mutations
that might otherwise cause disease.
It's going to enable a lot of science to be done
that was impossible to do in the past.
So the way the CRISPR technology works is
by the action of a protein called Cas9 that functions
like a molecular scalpel for DNA.
The CRISPR Cas9 system has an amazing ability
to recognize a particular DNA sequence in a cell that may be
malfunctioning, and then disable it by cutting the DNA.
We call this gene editing, and we can use it
to disable or repair a mutated part of the gene,
which may be causing disease.
For Cas9 to find the malfunctioning DNA,
we attach it to an RNA sequence
that matches the DNA sequence we want to edit.
Then we put this RNA Cas9 combination into the cell.
It finds the mutant DNA and uses the chemical reaction
to cut the DNA strand right at the spot
where it's malfunctioning.
After that, we can sometimes insert the correct version
of the gene for the cell to work properly again.
It's a very exciting technology that's going to do
a lot of good in human society and for human health.
It stretches from human therapeutics
to agricultural applications to thinking about
how do we make better biofuels.
These would be incredible outcomes, I think,
of using this kind of technology in the future.
(gentle percussive music)
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CRISPR-Cas9 gene editing and how it works - with Jennifer Doudna

50 Folder Collection
zywang published on March 9, 2020
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