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  • welcome to another MedCram update let's talk about California and testing but

  • before we do let's just review total confirm eighty 2164 total deaths 2800 oh

  • one total recovered thirty two thousand eight hundred and ninety seven we see

  • more of a continuation of what we've been seeing in the past let's go to the

  • world ometer we gonna talk a little bit about testing today and also the

  • positivity rate and UK they have well over seven thousand tests of which only

  • thirteen are positive and that's a very low positivity rate of course in Italy

  • where they actually have an outbreak they've done over nine thousand tests of

  • which only four hundred and seventy are positive it's about a five percent

  • positivity rate in France two point two positivity rate in Austria 321 tests of

  • which two are positive and then in the United States notice we've only done

  • four hundred and forty five concluded tests of which fourteen are positive and

  • that's around three point one positivity rate these tests are not as sensitive as

  • you may think that you're going to be surprised that the sensitivity on these

  • tests are only around seventy percent and so it is possible to have a negative

  • test and to still be infected with the corona virus we see that there are so

  • far 334 new cases and one death in South Korea and the number of confirmed cases

  • expected to jump in the coming days as health authorities have started testing

  • more than two hundred and ten thousand members of this church and Daegu if we

  • look at the numbers coming out of China and the rest of the world in terms of

  • the total deaths that seems to be leveling off and if we look at the

  • number of daily new cases outside of China that has hit its highest amounts

  • ever on February 26 with daily cases of 569 I want to go to a local site

  • Eyewitness News here in Southern California a new case

  • that has been detected in Northern California in a resident who has not

  • traveled overseas couple things that I want you to be

  • aware of this patient is a resident of Solano County turns out that Solano

  • County is the home to Travis Air Force Base where Americans returning from

  • overseas were quarantined the patient was transferred back on February 19th so

  • that was about a week ago from undisclosed hospital to UC Davis health

  • and that is the hospital in Sacramento for the University of California Davis

  • patient had already been intubated was on a ventilator and was given droplet

  • precautions orders because of an undiagnosed and suspected viral

  • condition so there are other viruses that can do this now at the time it

  • seems as though UC Davis had asked the CDC for testing but this was not done at

  • the time and if you go to the CDC website it tells you what their

  • requirements are for testing although they do put a disclaimer that they will

  • look at a case-by-case basis but essentially unless you traveled to Wuhan

  • or that part of China they weren't really going to be doing that kind of

  • testing so it's unclear how eventually UC Davis was able to get CDC to test

  • this patient but they did and eventually on Sunday the CDC ordered the Cova 19

  • testing of the patient at that time the patient was put into airborne

  • precautions what does this mean it means that anybody going into that room had to

  • have an n95 mask and had to go into contact isolation precautions that means

  • they would have to wear a gown gloves they may even have to wear I wear

  • protection if they were not able to do that then they would have to go under

  • something called poppers where they basically go in with a mask that was

  • vented from Sunday to Wednesday it took for the CDC to confirm finally that the

  • patient's test was positive the small number of employees were to go home and

  • monitor their temperature for any kind of fever or things of that nature

  • and the key here is to recognize apparently this patient had no travel to

  • that part of the world they go on to say here at this time the patient's exposure

  • is unknown it's possible that this could be an instance of

  • they call community spread of kovat 19 which would be the first time that this

  • has happened in United States it's also possible however they said

  • that the patient may have been exposed to a returned traveler who was infected

  • of course this brings up the issue of anybody that comes when with fever or

  • signs and symptoms of a viral illness and shortness of breath could be

  • potentially a carrier of this novel coronavirus and that's why it's really

  • important to have lots of personal protective equipment at hospitals where

  • they belong instead of running out at hospital so it's really important that

  • hospitals have the ability to acquire personal protective equipment because

  • you don't want to show up to a hospital where the employees there or the doctors

  • or the nurses don't have the adequate amount of protection so that they don't

  • pass the virus on to anybody else that might show up at that hospital so please

  • do not take masks and protective equipment from hospitals for your own

  • use but this really brings up a big issue and that is how do you test people

  • for coronavirus how do you know quickly whether or not this person that's coming

  • in has this virus obviously if we see here in this case it took them from

  • Wednesday when they actually got the causative test all the way from Sunday

  • when they first order the tests you can see that that's not the optimal

  • situation especially when we add to the situation that this test is not really

  • that sensitive meaning that if you have a negative test you can absolutely rule

  • it out so enter a study that I think is going to be important and that is this

  • science Daily News article which talks about this article that was just

  • published in radiology called CT provides the best diagnosis for kovat

  • 19:00 I will put a link to it in the description below basically what they

  • did is in China they looked at over a thousand patients and they did this

  • reverse transcriptase polymerase chain reaction which is what rt-pcr stands for

  • this is where you look for the actual RNA of the patients and compared it to

  • the classical findings that they see on CT scan here's another news item of the

  • same article so title as CT provides best diagnosis for kovat 19 and it says

  • the study from China shows that chest CT demonstrates better sensitivity than

  • this blood test looking for the actual pcr of the virus

  • remember that halfway through the epidemic last month they changed the

  • criteria in the definition for the diagnosis of kovat 19 so you can see

  • here in a study of more than a thousand patients that was published in the

  • journal article radiology which we link to so you can look at it for yourself

  • chest CT actually outperformed lab testing in the diagnosis of 2019 novel

  • coronavirus and this was looked at in Wuhan China so it's important to

  • understand that you have to make an early diagnosis of kovat 19 if you're

  • going to isolate and you're going to prevent the spread of that disease as we

  • talked about earlier in a early jam article 41 percent of patients who

  • contracted Co vyd 19 did so in the hospital and the majority of those 41

  • percent were healthcare workers according to the latest guidelines by

  • the Chinese government the diagnosis must be confirmed by reverse

  • transcriptase polymerase chain reaction or the gene sequencing they say here

  • however that those throat samples are only about 30 to 60 percent positive at

  • initial presentation having a low sensitivity implies that there's going

  • to be a lot of people who will be negative initially and you're gonna miss

  • those people those people are going to come through into your hospital and

  • potentially infect other people specifically people who are there to

  • help and causing them to be taken out of work and put into isolation most likely

  • and so they say here that early diagnosis of copán 19 is crucial for the

  • disease treatment and control compared to rt-pcr that is the genetic testing

  • they say here that chest CT imaging may be a more reliable practical and rapid

  • method to diagnose and assess kovat 19 especially in the epidemic area so why

  • did they think that well let's take a look and see this

  • there was over a thousand patients who underwent both CT chest and rt-pcr tests

  • from January 6 to February 6 and what they did was they looked at all of those

  • people who had a positive PCR and there was about six hundred and one of those

  • and everybody that had a positive CT scan and there was eight hundred and

  • eighty eight of those and then they asked the question well what's the

  • sensitivity what's the specificity and what's the accuracy and what they found

  • was that about eighty one percent of patients with a negative rt-pcr

  • but a positive CT scan were reclassified as highly likely or probable cases with

  • kovat 19 based on the comprehensive analysis of clinical symptoms typical CT

  • manifestations and dynamic CT follow-ups what they mean by that they were getting

  • worse and they were consistent they also found in a lot of these that the initial

  • tests may have been negative but that follow-up tests turned positive

  • confirming in a lot of these cases the original CT findings let's review those

  • results the results showed that 59 percent of these patients that they

  • tested had PCR results that were positive eighty eight percent had

  • positive CT scans they said that the sensitivity and this is something that

  • you want to be very very high in this situation because something that is very

  • sensitive means that if it is negative you can practically rule it out and as

  • it turned out that sensitivity of chest CT was 97% based on positive rt-pcr

  • results in patients with negative rt-pcr results seventy-five percent of those

  • patients had positive CT findings and of those forty eight percent were highly

  • likely cases so what we're seeing here is that CT scans may be the way to get a

  • quick screening of whether or not your patient with fever is likely to have

  • kovat 19:00 but the question is what are the findings on CT it's good enough to

  • know that you should get a CT but what is it that you should be looking for I'm

  • going to link in the description below a youtube video describes the findings

  • on CT scan of known cases of copán night and that concludes our update for today

  • realize that many of these videos are made the evening before they get

  • released because I still am working in the intensive care unit seeing patients

  • every single day and so this is something that I do at the end of the

  • day because we as healthcare providers are on the front line and we have to be

  • prepared thanks for joining us

welcome to another MedCram update let's talk about California and testing but

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