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  • As DNA is transcribed into RNA it needs to be edited to

  • remove non-coding regions, or introns, shown in green.

  • This editing process is called splicing,

  • which involves removing the introns,

  • leaving only the yellow, protein-coding regions, called exons.

  • RNA splicing begins with assembly of helper proteins

  • at the intron/exon borders.

  • These splicing factors act as beacons to guide small

  • nuclear ribo proteins to form a splicing machine,

  • called the spliceosome.

  • The animation is showing this happening in real time.

  • The spliceosome then brings the exons on either side of

  • the intron very close together, ready to be cut.

  • One end of the intron is cut and folded back on itself

  • to join and form a loop.

  • The spliceosome then cuts the RNA to release the loop and join the

  • two exons together.

  • The edited RNA and intron are released and

  • the spliceosome disassembles.

  • This process is repeated for every intron in the RNA.

  • Numerous spliceosomes, shown here in purple,

  • assemble along the RNA.

  • Each spliceosome removes one intron,

  • releasing the loop before disassembling.

  • In this example, three introns are removed from the RNA

  • to leave the complete instructions for a protein.

As DNA is transcribed into RNA it needs to be edited to

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B2 US rna loop coding edited protein shown

RNA Splicing

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    James posted on 2015/06/19
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