C1 Advanced US 1458 Folder Collection
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The menstrual cycle is a term used to describe monthly events that occur within a woman's
body in preparation for the possibility of pregnancy. Each month, an egg is released
from an ovary in a process called ovulation. At the same time, the lining of the uterus
thickens, ready for pregnancy. If fertilization does not take place, the lining of the uterus
is shed in menstrual bleeding and the cycle starts over.
An ovary contains hundreds of thousands of primary oocytes - immature eggs, or ova. Each
of these is enclosed in a structure called a follicle, and at this stage -- a primordial
follicle. The menstrual cycle is under control of hormones
secreted by the pituitary gland and the ovaries. The pituitary itself is under control of the
hypothalamus. The hypothalamus produces a hormone called
the gonadotropin-releasing hormone or GnRH. GnRH stimulates the anterior lobe of the pituitary
to secrete follicle-stimulating hormone (FSH). FSH travels in the bloodstream to the ovaries
and stimulates a group of follicles to grow. These primordial follicles develop into primary
follicles and then secondary follicles. These produce a hormone named estrogen which acts
to stimulate the growth of the endometrium -- the inner lining of the uterus. The secondary
follicles compete with each other and only one of them will survive and become a mature
follicle, the rest atrophy and die. The increasing level of estrogen also acts
on the hypothalamus and the anterior pituitary to increase the level of GnRH and induce the
production of another hormone -- luteinizing hormone (LH). A surge in LH secretion triggers
ovulation - the release of the egg from the follicle and the ovary. The egg is then swept
up by the fimbriae and taken into the uterine tube.
Fertilization by a spermatozoon, when it occurs, usually takes place in the ampulla, the widest
section of the fallopian tube. The fertilized egg immediately begins the process of development
while travelling toward the uterus. After 6 days it becomes a blastocyst and is implanted
into the endometrium of the uterus. Meanwhile, the left-over of the ruptured follicle
has become a corpus luteum which secretes progesterone. Progesterone further stimulates
uterine development making it a nutritious bed for the embryo in the event of pregnancy.
In the absence of pregnancy, the corpus luteum atrophies and progesterone level falls. This
leads to the breakdown of the endometrium, menstruation begins and the cycle starts over.
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Hormonal Control of the Menstrual Cycle, Animation.

1458 Folder Collection
Lizzy published on June 18, 2015
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