Name: 【TED-Ed】The past, present and future of the bubonic plague - Sharon N. DeWitte
Uploaded: 2014-12-29T19:04:39.000Z
Duration: 4 min 13 s
Description: Thousands of YouTube videos with English-Chinese subtitles! Now you can learn to understand native speakers, expand your vocabulary, and improve your pronunciation...

Imagine if half the people in your neighborhood, your city,

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or even your whole country were wiped out.

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It might sound like something out of  an apocalyptic horror film,

but it actually happened  in the 14th century

during a disease outbreak known as the Black Death.

Spreading from China through Asia, the Middle East, Africa and Europe,

the devastating epidemic destroyed  as much as 1/5 of the world's population,

killing nearly 50% of Europeans in just four years.

One of the most fascinating and puzzling things abut the Black Death

is that the illness itself was not a new phenomenon

but one that has affected humans for centuries.

DNA analysis of bone and tooth samples from this period,

as well as an earlier epidemic known as the Plague of Justinian in 541 CE,

has revealed that both were caused by Yersinia pestis,

the same bacterium that causes bubonic plague today.

What this means is that the same disease caused by the same pathogen

can behave and spread  very differently throughout history.

Even before the use of antibiotics, the deadliest oubreaks in modern times,

such as the ones that occurred in early 20th century India,

killed no more than 3% of the population.

Modern instances of plague also tend to remain localized,

or travel slowly, as they are spread by rodent fleas.

But the medieval Black Death, which spread like wildfire,

was most likely communicated directly from one person to another.

And because genetic comparisons of ancient to modern strains of Yersinia pestis

have not revealed any significantly functional genetic differences,

the key to why the earlier outbreak was so much deadlier

must lie not in the parasite but the host.

For about 300 years during the High Middle Ages,

a warmer climate and agricultural improvements

had led to explosive population growth throughout Europe.

the end of this warm period spelled disaster.

High fertility rates combined with reduced harvest,

meant the land could no longer  support its population,

while the abundant supply of labor kept wages low.

As a result, most Europeans in the early 14th century

experienced a steady decline in living standards,

marked by famine, poverty and poor health, leaving them vulnerable to infection.

And indeed, the skeletal remains of Black Death victims found in London

show telltale signs of  malnutrition and prior illness.

The destruction caused by the Black Death changed humanity in two important ways.

On a societal level, the rapid loss of population

led to important changes in Europe's economic conditions.

as well as more land and better pay for the surviving farmers and workers,

people began to eat better and live longer as studies of London cemeteries have shown.

Higher living standards also brought an increase in social mobility,

weakening feudalism, and eventually leading to political reforms.

But the plague also had an important biological impact.

The sudden death of so many of the most frail and vulnerable people

left behind a population with a significantly different gene pool,

including genes that may have helped survivors resist the disease.

And because such mutations  often confer immunities

to multiple pathogens  that work in similar ways,

research to discover the genetic consequences of the Black Death

has the potential to be hugely beneficial.

Today, the threat of an epidemic  on the scale of the Black Death

has been largely eliminated  thanks to antibiotics.

But the bubonic plague continues to kill a few thousand people worldwide every year,

and the recent emergence of a  drug-resistant strain

Learning more about the causes and effects of the Black Death is important,

not just for understanding how our world has been shaped by the past.

It may also help save us from  a similar nightmare in the future.