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  • I want you guys to imagine that you're a soldier running through the battlefield.

  • Now, you're shot in the leg with a bullet, which severs your femoral artery.

  • Now, this bleed is extremely traumatic and can kill you in less than three minutes.

  • Unfortunately, by the time that a medic actually gets to you,

  • what the medic has on his or her belt can take five minutes or more,

  • with the application of pressure, to stop that type of bleed.

  • Now, this problem is not only a huge problem for the military,

  • but it's also a huge problem that's epidemic throughout the entire medical field,

  • which is how do we actually look at wounds and how do we stop them quickly in a way that can work with the body?

  • So now, what I've been working on for the last four years is to develop smart biomaterials,

  • which are actually materials that will work with the body, helping it to heal

  • and helping it to allow the wounds to heal normally.

  • So now, before we do this, we have to take a much closer look at actually how does the body work.

  • So now, everybody here knows that the body is made up of cells.

  • So the cell is the most basic unit of life. But not many people know what else.

  • But it actually turns out that your cells sit in this mesh of complicated fibers,

  • proteins and sugars known as the extracellular matrix.

  • So now, the ECM is actually this mesh that holds the cells in place,

  • provides structure for your tissues, but it also gives the cells a home.

  • It allows them to feel what they're doing, where they are,

  • and tells them how to act and how to behave.

  • And it actually turns out that the extracellular matrix is different from every single part of the body.

  • So the ECM in my skin is different than the ECM in my liver,

  • and the ECM in different parts of the same organ actually vary,

  • so it's very difficult to be able to have a product that will react to the local extracellular matrix,

  • which is exactly what we're trying to do.

  • So now, for example, think of the rainforest.

  • You have the canopy, you have the understory, and you have the forest floor.

  • Now, all of these parts of the forest are made up of different plants,

  • and different animals call them home.

  • So just like that, the extracellular matrix is incredibly diverse in three dimensions.

  • On top of that, the extracellular matrix is responsible for all wound healing,

  • so if you imagine cutting the body, you actually have to rebuild this very complex ECM

  • in order to get it to form again,

  • and a scar, in fact, is actually poorly formed extracellular matrix.

  • So now, behind me is an animation of the extracellular matrix.

  • So as you see, your cells sit in this complicated mesh

  • and as you move throughout the tissue, the extracellular matrix changes.

  • So now every other piece of technology on the market

  • can only manage a two- dimensional approximation of the extracellular matrix,

  • which means that it doesn't fit in with the tissue itself.

  • So when I was a freshman at NYU, what I discovered was

  • you could actually take small pieces of plant-derived polymers and reassemble them onto the wound.

  • So if you have a bleeding wound like the one behind me, you can actually put our material onto this,

  • and just like Lego blocks, it'll reassemble into the local tissue.

  • So that means if you put it onto liver, it turns into something that looks like liver,

  • and if you put it onto skin, it turns into something that looks just like skin.

  • So when you put the gel on, it actually reassembles into this local tissue.

  • So now, this has a whole bunch of applications,

  • but basically the idea is, wherever you put this product, you're able to reassemble into it immediately.

  • Now, this is a simulated arterial bleedblood warningat twice human artery pressure.

  • So now, this type of bleed is incredibly traumatic, and like I said before,

  • would actually take five minutes or more with pressure to be able to stop.

  • Now, in the time that it takes me to introduce the bleed itself, our material is able to stop that bleed,

  • and it's because it actually goes on and works with the body to heal,

  • so it reassembles into this piece of meat,

  • and then the blood actually recognizes that that's happening,

  • and produces fibrin, producing a very fast clot in less than 10 seconds.

  • So now this technologyThank you.

  • So now this technology, by January, will be in the hands of veterinarians,

  • and we're working very diligently to try to get it into the hands of doctors, hopefully within the next year.

  • But really, once again, I want you guys to imagine that you are a soldier running through a battlefield.

  • Now, you get hit in the leg with a bullet, and instead of bleeding out in three minutes,

  • you pull a small pack of gel out of your belt, and with the press of a button,

  • you're able to stop your own bleed and you're on your way to recovery.

  • Thank you very much.

I want you guys to imagine that you're a soldier running through the battlefield.

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B1 TED extracellular matrix bleed mesh body

【TED】Joe Landolina: This gel can make you stop bleeding instantly (Joe Landolina: This gel can make you stop bleeding instantly)

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    Go Tutor posted on 2014/12/27
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