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  • Thank you so much to the SENS Research Foundation for sponsoring this video!

  • Oh, hey!

  • You caught me watching my favorite zombie show, The Blocking Dead.

  • It's on its 75th season and I truly have no idea what's happening anymore, but this show reminded me of a fun video idea.

  • Did you know that an entire army of zombies is living inside you; and it's getting larger every day!

  • Yeah. Buckle up. Queue the intro!

  • Hey there! Welcome to Life Noggin!

  • It's true! There's a horde of zombies living inside you. Zombie cells that is.

  • The cells in your body are continually dividing and replacing old or damaged tissue, and repairing wounds.

  • This is what keeps you healthy.

  • But eventually, due to cellular stress, they stop multiplying.

  • And, instead of being killed through a process known as apoptosis, or cleared from the body by the immun system,

  • they remain and release harmful substances called SASP.

  • SASP stands for scenscent-associated secretory phenotype, and they can destroy or impair the cells around them.

  • The cells that release SASP, or just won't go away, are called senescent cells or zombie cells.

  • And, as you age, you get more and more of them,

  • leading to age-related disorders like cancer, cardiovascular disease, dementia, osteoporosis, and metabolic diseases.

  • The development of these cells is considered a hallmark of aging.

  • But scientists are finding ways to slow down their buildup or even remove them in order to prevent or treat age-related disease, and ultimately, extend one's lifespan.

  • There are three main methods being explored and they are all fascinating!

  • The first and most popular are senolytics.

  • These are drugs that target and kill senescent cells by inducing apoptosis.

  • There are many senolytics being tested in animals, and some even in clinical trials with varying success,

  • as well as targeted delivery strategies to mitigate serious side effects like tissue dysfunction.

  • Another strategy is SASP inhibitors or senomorphics, these drugs can stop the zombie cells from sucreating SASP,

  • so it can prevent it from damaging nearby cells, or even worse, by creating more zombie cells.

  • The last method is boosting our immunosurveillance, by strengthening the immune system so it can recognize and eliminate senescent cells by itself.

  • All three approaches have pros and cons, but they follow a broader theory of how to stop aging, by stoping the buildup of senescent cells,

  • this is called the damage repair approach.

  • Preventing damage would require messing with a complicated and delicate system.

  • But waiting for the disease to occur may be too late.

  • Treating the body as the damage accumulates, however... that could work!

  • And not just with these zombie senescent cells, but all types of age-related damage.

  • Which is exactly what our sponsor, the SENS Research Foundation, is working on with ApoptoSENS and other programs.

  • Check out their links in the description to learn more about the amazing work they are doing!

  • Did you like this video?

  • If so, we can make more about the other types of damage in the body, and how to perhaps stop them.

  • Let us know!

  • And also let me know in the comment section below, would you wanna live to 200 if nothing bad would happen to your body?

  • Let's have a fun discussion, shall we?

  • Don't forget to subscribe and click the bell so you're notified every single time we upload a new video, and don't forget to click like because it really helps us out!

  • You can also check out the team at Lifespan that powers Life Noggin down in the description!

Thank you so much to the SENS Research Foundation for sponsoring this video!

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