B1 Intermediate US 44 Folder Collection
After playing the video, you can click or select the word to look it up in the dictionary.
Loading...
Report Subtitle Errors
What makes Cancer…
Cancer?
Every cell in your body is controlled by a network of molecules that coordinate all of
the cell's basic functions.
This network maintains a steady pattern of signals that can respond to changes in the
environment.
Cancer works by hijacking this network, forcing it to focus on one thing: growth.
A cell with cancer will keep dividing under any circumstances — well beyond the point
when a healthy cell would self-destruct.
That's what makes cancer so hard to treat: they are your own body's cells, but reprogrammed
to multiply without limits.
The first drugs that were developed to treat cancer were aimed at this growth behavior.
Cytotoxic chemotherapy drugs wipe out any cells that multiply too quickly, often by
interfering with the DNA-copying machinery of the cell.
That's also why traditional therapies come with so many negative side effects.
An alternate approach is to use targeted drug therapies.
Targeted therapies knock out individual proteins in the hijacked network that causes the uncontrolled
growth.
But, while shutting down a single protein in the signalling network might work for a
time, cancer cells can adapt, causing patients to relapse.
One way to defeat cancer's cleverness is to target several proteins at the same time
— that's where drug combinations, or “cocktails,” come in.
With two, three, or several drugs all targeting different parts of the network, the potential
for effective treatment is greater.
Even better, these treatments can be tailored to individual patients.
Because of the complexity of the network, two people with the same diagnosis can respond
differently to the same combination of drugs.
This is where personalized medicine can help.
But how do we find the most effective drug combinations for each person?
For each new drug developed, the number of possible combinations increases exponentially--resulting
in millions of possible treatments.
It would be practically impossible to experimentally find the right combination for each individual
patient.
Instead, our lab is trying to move that trial and error process from the lab to the computer.
By simulating the cell signalling network and the effects that the drugs have on cancer
cells, we can rewrite the network as a system of mathematical rules,
and use it to see what happens when multiple drugs interact.
This way, we can try out many, many drug combinations in a virtual environment, and test only the
most effective ones in the lab.
The idea is to move away from guesswork, and apply an engineering mindset to the problem.
It's the right combination to discover tomorrow's anti-cancer therapy.
    You must  Log in  to get the function.
Tip: Click on the article or the word in the subtitle to get translation quickly!

Loading…

Can computers help cure Cancer?

44 Folder Collection
OolongCha published on August 12, 2020
More Recommended Videos
  1. 1. Search word

    Select word on the caption to look it up in the dictionary!

  2. 2. Repeat single sentence

    Repeat the same sentence to enhance listening ability

  3. 3. Shortcut

    Shortcut!

  4. 4. Close caption

    Close the English caption

  5. 5. Embed

    Embed the video to your blog

  6. 6. Unfold

    Hide right panel

  1. Listening Quiz

    Listening Quiz!

  1. Click to open your notebook

  1. UrbanDictionary 俚語字典整合查詢。一般字典查詢不到你滿意的解譯,不妨使用「俚語字典」,或許會讓你有滿意的答案喔