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  • Your brain contains billions of cells.

  • They consist of a cell body, dendrites and an axon.

  • The cell body stores DNA and other stuff.

  • Dendrites receive signals from other cells

  • and the axon carries signals from the cell body to the axon terminals.

  • Axon terminals contain neurotransmitters,

  • which serve to communicate with other cells.

  • Some cells contain just one type of neurotransmitter.

  • Serotonin cells only produce and release serotonin.

  • Serotonin cells release their serotonin into the synapse.

  • This is the gap between their axon terminals and the dendrites of another cell.

  • Serotonin is involved with the regulation of your mood, heart rate, sleep and -

  • - appetite.

  • MDMA causes cells to release large amounts of serotonin.

  • These large amounts are responsible for the primary effects of MDMA,

  • such as: euphoria, empathy, the urge to communicate and mild hallucinations.

  • Side effects are increased heart rate, difficulty sleeping and loss of appetite.

  • Serotonin is stored in vesicles that float around inside the axon terminals.

  • When a signal comes down the axon the vesicles merge with the membrane -

  • and releases serotonin into the synapse.

  • Released serotonin can enter a different cell through receptors

  • that are attachted to the membrane of dendrites.

  • When serotonin attaches to such a receptor, the receptor sends information -

  • - to the cell body.

  • Based on the information from all the receptors together the cell body -

  • - will decide whether or not to send a signal down it's own axon.

  • When it does send a signal more serotonin gets released into more synapses.into more synapses

  • After a while the serotonin will detach from the receptor and float back into the synapse.

  • Serotonin can also bind to re-uptake transporters.

  • Re-uptake transporters work as a revolving door.

  • After the serotonin enters, the transporter spins around and -

  • - pushes the serotonin back into the axon terminal.

  • Some serotonin makes it way back into the vesicles, but some of it gets broken -

  • - down by an enzyme called monoamine oxidase.

  • After four to six hours you've used up most of your serotonin

  • and you should start to feel somewhat normal again.

  • However, your low serotonin levels can make you feel depressed, extremely -non-social and tired.

  • Your brain needs time to rebuild your serotonin levels. This could take up to two weeks.

  • MDMA causes the release of serotonin by entering the axon terminal through the re-uptake transporters.

  • Once there, it interacts with the vesicle, causing it to poor serotonin into the synapse.

Your brain contains billions of cells.

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