Name: 19. Cholesterol Biosynthesis 1
Uploaded: 2020-03-29T16:22:32.000Z
Duration: 51 min 28 s
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JOANNE STUBBE: What I want to do is sort of introduce you

to the second half of the course, where we're going,

and what topics we're going to be covering.

So as with the first half of the course, we have four modules.

The first half the courses was pretty well organized--

that is, you went from here to here to here.

of topics in biochemistry, and any one of them

And these are the ones we're talking about this semester.

So in module 5, we're going to be talking about the terpenome.

And I'm going to be talking about, most of you

have seen in the last module, with polyketide synthases,

you have aldol reactions and claison reactions

In this module, you're going to be introduced to another way

And C5 units are the basis for forming cholesterol, which is

And then you all know from eating McDonald's hamburgers,

you get a lot of cholesterol in your diet.

And the question is, how do you control cholesterol levels?

And so this semester, the second part of the semester

is really focus on the question of homeostasis.

If you have too much you've got problems.

Doesn't matter what pathway you're talking about,

if you have too much or you have too little, you have problems.

And we're going to be talking about cholesterol sensing

And we're going to come back to a topic you covered

in the first half of the course with ClpX and ClpP protein

a central role in controlling cholesterol homeostasis.

So that will be the first module, module 5.

Module 6 is also going to be a module on homeostasis.

It's my feeling that in introductory courses,

people don't get introduced enough to metals.

But we're going to talk about iron sensing and regulation,

going to focus on the war between pathogenic organisms

is essential for almost all organisms to survive.

module 7-- sort of follows from module 6.

And it's a topic that I've been following for 30 years,

So everybody talks about reactive oxygen species,

So we'll define what reactive oxygen species are.

That's why you eat vitamin C and vitamin E.

And they're involved, in fact, in defense

They're now known to be involved in signaling.

So again, it's a question of homeostasis.

And so you need to understand the chemistry

of what these species do, and where they can go astray,

And the last section-- hopefully we'll get there this year,

we're going to talk about nucleotide metabolism.

In 5.07, they don't talk about nucleotide metabolism at all.

you're going to see a lot about nucleotide metabolism.

Where have you seen ATP and GTP in the first part

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19. Cholesterol Biosynthesis 1

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