US /ˈvɛsɪkəl/
・UK /ˈvesɪkl/
The vesicles that bud from the rough ER are coated, which helps in vesicle formation and facilitates the transport of the cargo protein to the Golgi apparatus.
essentially what happens is, for example, you have endocytosis, where the cell forms a vesicle containing possibly unwanted materials.