Name: 【TEDx】You can't always blame your parents: Alberto Perez at TEDxSBU
Uploaded: 2014-01-28T12:31:24.000Z
Duration: 12 min 16 s
Description: Thousands of YouTube videos with English-Chinese subtitles! Now you can learn to understand native speakers, expand your vocabulary, and improve your pronunciation...

Adverbs of degree

We all know how bees live in very organized societies.

They work together for the good of the colony

and they actually divide the work between themselves.

they go out from the colony to look for food.

they stay in the colony taking care of it.

Both kind of bees have actually the same DNA, the same information that made them,

but their behavior is completely different.

And you can actually see that the information that they use from their DNA is completely different.

There are actually some markers on top of their DNA

that is changing how this information can be used.

Now, imagine that we take away all the nurses from the colony while the foragers are gone.

When they come back, some of them are going to start working as nurses

not only is their behavior going to change, but also what information they are using from their DNA.

Those markers are also going to be changing.

And what i want to tell you about today is about this new exciting research

about how those markers can affect the information on your DNA,

how they are affected by our environment and the decisions we make and how they can influence your lives.

I actually got interested in DNA when I was a kid. I was very confused.

Just imagine growing up as a red head in Spain. I got asked quite a lot of times if I was lost in my own town.

And actually both my parents and brother have dark hair and most of the kids in my school also had dark hair.

So I was really wondering where I was coming from, if I was adopted and all those kind of things that kids usually worry about.

So, when I actually asked my dad about it, he said: "it's all in your DNA".

And that wasn't the answer I was looking for, but it did get me interested about DNA and how it works.

And we actually know from shows like CSI and Jurassic Park that DNA is a unique fingerprint for each one of us,

it has all the information to make one of us.

And one of the first questions I had is: well, we are complex, how much DNA do we actually need

It is made up from smaller building blocks, just like LEGOs,

they are stacked on top of each other making the shape of a double helix.

The more building blocks you put, the longer and longer the helix becomes.

There are actually only 4 building blocks. They are called A,C,G and T for the names of the molecules they represent.

And what's cool about them is that the order this blocks are placed in actually codes for information about us

So, this information might actually look something like this.

And to you and I, this might not make much sense,

but inside of our bodies that information can be turned into something useful for our bodies

in pretty much the same way that a computer code of 1s and 0s is used in our phones to make the apps that we use.

So, the complete set of instructions to make one of us is actually 3 billion letters long.

You can think of the genome as a library containing all the information about us.

Where each one of the books contains information about how to make one specific

And instead of having just one copy of this library somewhere inside us,

we have multiple copies. In fact, we have one identical copy in each one of our cells.

So that when a cell needs something it goes to its library, looks for the information and then uses it.

Now, there are several trillion cells inside of our body.

So if I actually take all the DNA from my cells and put it together in a straight line,

there is enough DNA to go all the way from this room to the sun and back...

So that's how much DNA there is inside of us. And we need some way to keep that DNA inside of us

and also make the information available to us.

Just imagine what happens whenever you take your earphones and put them in your pocket

when you take them out again they are probably going to come out like a tangled mess.

You can't use them right away. If the same happens to our DNA, then we would die.

So we actually need a quite good mechanism to store the information.

And actually the way this information is stored in each cell, determines what information from the DNA we can use.

So in the example from the library just think about different layouts of the books.

Those books that are on shelves that are very easy to access are going to be used a lot.

Where as those that are stored far away in high shelves, they might never be used.

Just imagine cells from your eyes, heart and stomach. They have very different needs,

they need to access different information to carry out their work.

And this is done by storing the information in different ways.

What actually controls this is something called epigenomics.

This literally means: "On top of the DNA"

and this a set of markers that act to store that information in different ways,

so that we can use different information in each one of our cells.

In the example of the bees, those markers were the ones responsible for making the behavior of those bees be different

they could access different information and their behavior was different.

And one way to think about this markers is like punctuation marks on a text.

Imagine the next two sentences: "Let's eat, mommy!" or "Let's eat mommy!".

They have exactly the same letters, the same words, but the meaning is completely different just by changing a small punctuation mark

And actually the same happens with our DNA.

Where those markers are placed are going to affect what information our cells can use.

And this is actually good. So just imagine though what happens to those markers.

They can actually be affected by our environment and the decisions we make.

Things like stress, sun exposure, diet, smoking, exercise,...

all these things can change where those markers are placed.

Imagine for example identical twins. They have exactly the same DNA but their appearance might be different.

One of them might be taller, or bulkier, or even have different eye color.

When they were initially made they had the same DNA and exactly the same markers.

But as they go through their lives and are exposed to different environments and different decisions,

their markers appear in different places and that makes their appearance also become different

Not only that, but the way those markers are placed can stay through a long time.

In fact some times, those markers can be passed on to the next generation.

And I have an example from a northern region of Sweden.

About 200 years ago this region was very isolated from the rest of the world.

So what they could eat was actually affected by how good the harvest was.

If the harvest was good, those were bountiful years, they could eat plenty of food during the whole year.

Whereas if the harvest was bad, then food would become scarce.

And of course, this scarcity or abundance of food influenced on how long this people were able to live.

But more important than that, it also affected the markers on their DNA.

And it so happens that if those markers where placed during a critical period of their development,

just before puberty, then those markers could be passed on to their children and even to their grandchildren.

So imagine what that means. What that means is that if I'm here right now,

how long i might leave, might depend on what my grandparents or my parents where eating during their childhood