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  • The novel coronavirus has been declared a global health emergency by the World Health Organisation.

  • So how are scientists responding?

  • And what can science do to help control the outbreak?

  • A top priority is epidemiology.

  • Epidemiologists are on the front line, trying to understand how and why the virus is spreading.

  • They gather data on the timing and location of new cases, where new infections are coming from and how long symptoms take to appear.

  • These data go into models that can predict how fast the infection might spread.

  • This is critical for both creating containment plans, and assessing whether counter-measures are actually working.

  • By looking at the patterns of spread, epidemiologists can infer the mode of transmission, such as in saliva or through the air.

  • Epidemiologists also need to know whether people who are infected but not showing symptoms could still pass on the disease, something which would make this coronavirus harder to wipe out.

  • Understanding the source of the virus is also important.

  • The virus likely originated in an animal before jumping to a human host.

  • Genetic analysis of samples taken from the market in Wuhan, where the outbreak started, could tell scientists which animal and help prevent future outbreaks.

  • Understanding how the virus spreads is a vital first step for containing it, but scientists also need to know how the virus itself functions.

  • And that is the job of virologists.

  • Across the world, virologists are scrambling to get their hands on physical samples of the novel coronavirus.

  • This work involves growing the virus in cultured cells and infecting animals in order to study it closely.

  • There's lots to learn.

  • Virologists can measure the survival time of the virus in droplets like those from a cough or a sneeze.

  • Animal models may show how the infection actually gets passed between individuals.

  • And working out the structure of viral proteins and the identity of the receptors they use to enter cells could inform potential treatments.

  • The genome of the virus can also hold clues.

  • Genetic sequences from dozens of patient samples are publicly available and have already been used to develop diagnostic tests.

  • But actual samplesin human cell cultures and animal models - will be needed to test vaccines and drugs.

  • This is where biomedical science comes in.

  • Drug development is a slow process, so researchers are having to work fast to find therapies for this new threat.

  • One of the most powerful tools biomedical scientists could develop is a vaccine, but this is a longer term solution.

  • A more imminent possibility is to inject patients with antibodies against the virus.

  • Finding antibodies that recognise it might not be so difficult, but mass producing enough antibodies, even for trials, could take months.

  • Antiviral drugs are also an option.

  • These are small molecules that interfere with viral replication, but developing them from scratch takes years.

  • So researchers are hoping that drugs already developed to treat things like HIV, could prove effective and trials have already started.

  • If counter-measures fail, coronavirus could become what's called 'endemic', recurring regularly like the flu.

  • That would make it extremely hard to eradicate.

  • Fighting this outbreak will require a range of scientific tools, from genetic sequencing to mathematical modelling.

  • And for all of that, researchers need data.

  • Many publishers and labs have made commitments to make all research free to access, encouraging collaboration and prioritising global health.

  • Time will tell how successful it will be.

The novel coronavirus has been declared a global health emergency by the World Health Organisation.

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