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  • DNA contains the genetic code found in all known life on our planet.

  • In each of nearly all of your roughly 30 trillion cells, there are 6.4 billion letters of DNA.

  • It's powerful stuff.

  • If the DNA in all of your cells was used to store computer data, it could hold the equivalent of all the digital data we currently store on Earth.

  • I'm Paul Nurse, and I've spent much of my working life thinking about DNA, in particular how it's copied and distributed inside cells every time they divide.

  • I was awarded the Nobel Prize for this work in 2001.

  • Our understanding of deoxyribonucleic acid, or DNA, has grown enormously since its discovery in the 19th century.

  • DNA was shown to be responsible for genetic inheritance in 1944.

  • Then, in 1953, its structure was revealed using X-rays.

  • And DNA turns out to be a stunningly elegant molecule.

  • What you're looking at is the original DNA model, currently on display in the Science Museum in London.

  • It shows two long chains of molecules spiralling around each other in a double helix, like a twisted ladder.

  • The rungs are pairs of four chemicals marked as A, G, C and T.

  • Determining the order of these chemicals - their sequence - is known as sequencing.

  • Being able to describe the DNA sequence allows scientists to identify important differences between individuals.

  • These unique differences have become the basis for what is known as our DNA fingerprint.

  • The first ever recorded DNA fingerprint was made in 1984 by my friend Alec Jeffreys at the University of Leicester.

  • Using DNA taken from his technician Vicky Wilson, he described not only which parts of her DNA came from her mother and which from her father,

  • but also the unique genetic code she possessed - one shared by no other human being.

  • DNA fingerprints can prove identity, how we are related and more.

  • DNA testing of hair, skin cells or blood found at crime scenes is now the gold standard for conviction - or exoneration - of suspects.

  • It has revolutionised the criminal justice system.

  • In 2000, the first draft human genome - all the DNA needed to build a human being - was unveiled.

  • And with the ability to read genomes came new insights into how the human body works and how we evolve.

  • Analysing DNA sequences has now reached the public in the form of commercial genetic testing by companies such as Ancestry and 23andMe.

  • By sending a saliva sample - and a fee, of course - anyone can receive a report containing information such as where their ancestors were from and who they are related to.

  • This ability to analyse DNA has had a personal consequence for me.

  • It's a twist of fate that although I have a long career in genetics, I never realised that my own family had a DNA secret.

  • When I was in my 50s, I found out that the person I'd thought was my sister was, in fact, my mother.

  • My parents - the people who raised me - were, in fact, my grandparents.

  • For a long time, the identity of my father remained a mystery.

  • But amazingly, now in my 70s, recently it was possible to identify him through DNA testing.

  • Analysing DNA has also enabled scientists to do many extraordinary things,

  • ranging from predicting genetic diseases to studying extinct members of the human family, like Neanderthals, and extinct animals like mammoths.

  • A new frontier in genetics is CRISPR, a gene-editing tool that works like molecular scissors, enabling scientists to cut and paste fragments of DNA within cells.

  • This means genetic diseases such as haemophilia, muscular dystrophy and cancers, in principle, might be "corrected" by editing the DNA of human embryos.

  • This has the potential to improve many people's lives, though more research is still required because like all new therapies, they have to be shown to be safe.

  • There are also questions that need to be answered about making changes that can be passed on to future generations.

  • But societies have navigated the challenges that come with new scientific technologies before.

  • DNA is the stuff of life.

  • It is inevitable that the more we research, the more we will understand about ourselves and the living world, and the more power we will have to change it.

  • All this work with DNA will give insights into human development,

  • allow us to study extinct species and help doctors to treat diseases like cancer with medicine better personalised for everyone's unique genetic makeup.

  • And we are also starting to make new genetic materials, creating new synthetic proteins that could be used, for example, to help break down pollutants or to reduce greenhouse gases.

  • Seven decades after the structure of DNA was first revealed, the DNA revolution continues to be exciting.

  • It shows no signs of slowing down.

DNA contains the genetic code found in all known life on our planet.

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