Name: 【TED-Ed】What causes antibiotic resistance? - Kevin Wu
Uploaded: 2014-09-10T01:16:35.000Z
Duration: 4 min 35 s
Description: Thousands of YouTube videos with English-Chinese subtitles! Now you can learn to understand native speakers, expand your vocabulary, and improve your pronunciation...

What if I told you there were trillions of tiny bacteria all around you?

Microorganisms called bacteria were some of the first life forms

Though they consist of only a single cell,

their total biomass is greater than that of all plants and animals combined.

on the ground, in the water, on your kitchen table, on your skin,

Don't reach for the  panic button just yet.

Although you have 10 times more bacterial cells inside you

than your body has human cells, many of these bacteria are harmless

or even beneficial, helping digestion and immunity.

But there are a few bad apples that can cause harmful infections,

from minor inconveniences to deadly epidemics.

Fortunately, there are amazing medicines designed to fight bacterial infections.

Synthesized from chemicals or occurring naturally in things like mold,

these antibiotics kill or neutralize bacteria by interrupting cell wall synthesis

or interfering with vital processes like protein synthesis,

The deployment of antibiotics  over the course of the 20th century

has rendered many previously dangerous diseases easily treatable.

But today, more and more of our antibiotics

Did something go wrong to make them stop working?

The problem is not with the antibiotics but the bacteria they were made to fight,

and the reason lies in Darwin's theory of natural selection.

Just like any other organisms, individual bacteria can undergo random mutations.

Many of these mutations are harmful or useless,

but every now and then, one comes along that gives its organism

And for a bacterium, a mutation making it resistant

to a certain antibiotic gives quite the edge.

As the non-resistant bacteria are killed off,

which happens especially quickly in antibiotic-rich environments,

like hospitals, there is more room and resources

for the resistant ones to thrive, passing along only the mutated genes

Reproduction isn't the only way to do this;

some can release their DNA upon death to be picked up by other bacteria,

while others use a method called conjugation,

connecting through pili  to share their genes.

Over time, the resistant genes proliferate, creating entire strains of resistant super bacteria.

So, how much time do we have before these superbugs take over?

Well, in some bacteria, it's already happened.

For instance, some strands  of staphylococcus aureus,

which causes everything from skin infections to pneumonia and sepsis,

have developed into MRSA, becoming resistant to

beta-lactam antibiotics, like penicillin, methicillin, and oxacillin.

Thanks to a gene that replaces the protein

beta-lactams normally target and bind to,

MRSA can keep making  its cell walls unimpeded.

even sometimes produce enzymes like beta-lactams

that break down antibiotic attackers before they can do any damage,

and E. coli, a diverse group of bacteria that contains strains that cause

diarrhea and kidney failure, can prevent the function

of antibiotics, like quinolones, by actively booting

any invaders that manage to enter the cell.

Scientists are working to stay one step ahead of the bacteria,

and although development of new antibiotics has slowed in recent years,

the World Health Organization has made it a priority to develop novel treatments.

Other scientists are investigating alternate solutions,

such as phage therapy or using vaccines to prevent infections.

Most importantly, curbing the excessive and unnecessary use of antibiotics,

such as for minor infections that can resolve on their own,

as well as changing medical practice to prevent hospital infections,

can have a major impact by keeping more non-resistant bacteria alive

In the war against super bacteria, deescalation may sometimes work better