Name: 【TED-Ed】RNAi: Slicing, dicing and serving your cells - Alex Dainis
Uploaded: 2014-08-12T14:06:06.000Z
Duration: 4 min 8 s
Description: Thousands of YouTube videos with English-Chinese subtitles! Now you can learn to understand native speakers, expand your vocabulary, and improve your pronunciation...

Reflexive pronouns

the chef looks to the cookbook, your DNA,

and brings it back to her countertop, the ribosome.

There, she can translate the recipe into a meal,

by following the directions that she's copied down.

it can direct amino acids to their targets,

Why would RNA want to interfere with itself?

Well, sometimes a cell doesn't want to turn

all of the messenger RNA it creates into protein,

or it may need to destroy RNA injected into the cell

Say, for example, in our cellular kitchen,

that someone wanted to cancel their order

or decided they wanted chips instead of fries.

Thankfully, your cells have the perfect knives

and they're picked up by something called RISC,

It's composed of a few different proteins,

using the single strand to target matching mRNA,

When it finds the matching piece of mRNA,

preventing the mRNA from being turned into protein.

So, how did anybody ever figure this out?

Well, the process was first discovered in petunias

when botanists trying to create deep purple blooms

introduced a pigment-producing gene into the flowers.

Instead of using the RNA produced by the new gene

to knock down the pigment-producing pathway,

from the plant's original genes with RNAi,

and leaving them with pigment-free white flowers.

and once they figured out what was happening,

when a certain gene is knocked out of a worm

Introduce an RNAi construct for that gene,

and target that effect to certain systems,

when you knock down a gene in a certain system

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【TED-Ed】RNAi: Slicing, dicing and serving your cells - Alex Dainis

figure

create

advantage

protein