Name: The Two Viruses That We’ve Had For Millions of Years
Uploaded: 2021-05-02T02:09:10.000Z
Duration: 9 min 31 s
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Sometime in the distant past, between about 3 million and 1.4 million years ago, a hominin

Relative clauses (Restrictive vs. nonrestrictive)

in Africa had a meal that would affect humanity forever.

This hominin probably consumed the meat of another primate -- specifically, one belonging

to the species from which chimpanzees and bonobos both evolved.

We don't know if the hominin hunted down that ancestral-chimp or just scavenged its

remains, but it's safe to assume that removing the meat from its bones was not a clean task.

While tearing up the carcass, it would've gotten blood on its hands, and maybe some

of it got into cuts or sores on its skin.

And this scenario likely played out before we see the control of fire in the archaeological

record, so that ancestral-chimp meat would've been eaten raw.

Now, while this part of the story is speculative, we think we know what the outcome was.

And we can use that end-point to come up with hypotheses about what might've happened

And one of those hypotheses is that this ancient hominin may have gotten more than it bargained

It might have contracted a virus — one that's stayed with humanity for millions of years,

even before our species existed, and which has been passed down to us.

The virus that we commonly call herpes is just one member of a very large group of viruses

known as herpesviruses, which are a very old lineage of DNA viruses.

There are lots of different kinds of herpesvirus, and they've been infecting vertebrates and

codiverging with them for millions of years.

As each species split off from its common ancestor, the viruses did, too.

This means the family tree of the virus mirrors the family tree of their hosts.

And in primates, the family tree of herpesviruses mostly matches up with the part of the primate

tree that includes monkeys, apes, and humans.

Scientists think this pattern of co-diverging goes back at least 44 million years, when

New World and Old World Monkeys split off from their common ancestor.

So, basically, there's one kind of herpesvirus that's specific to one species of primate,

and each virus split off from the herpesvirus family tree when the primate split off from

But of course, humans are a special kind of primate.

We're the only primate we know of to be infected by two kinds of herpesviruses: There's

HSV1, or oral herpes, which causes cold sores, and there's HSV2, which causes genital herpes.

Both viruses are transmitted by direct, skin-to-skin contact with the infected area, or with a

sore, or with saliva, or with genital secretions that are infected with the virus.

And while these viruses mostly don't cause symptoms, when they do, it's generally in

the form of painful blisters in the affected area.

Now, our closest living relatives, chimps, have their own herpesvirus, called ChHV1.

And in them, it causes oral symptoms just like HSV1 does in us.

But it turns out, the virus that causes genital herpes in humans is actually more closely

related to chimp herpes than it is to our own cold-sore virus.

Which is weird, since these related viruses infect different hosts.

So, the simplest explanation for this is that, at some point in the distant past, ChHV1 -- the

It went from some early, proto-chimp to one of our hominin relatives -- possibly through

the pathway I just described, with a hominin handling the butchered remains of a primate.

And from there, the virus went on to evolve into what's now one of the most common sexually

That means the origin of our HSV2 -- genital herpes -- was as a zoonotic disease - one

that moved from an animal into, in this case, a human relative.

And that puts it in pretty infamous company, like HIV, classic SARS, MERS, Ebola, and,

yes, probably also SARS-CoV-2, the coronavirus that causes COVID-19, although we don't

know yet what its original animal host was.

Now, figuring out how and when viruses are transmitted and switch between hosts is hard,

It takes the efforts of scientists from lots of different fields, and often many long years

So, imagine trying to do all that in organisms that lived millions of years ago.

Two groups of scientists have taken a crack at figuring out the history of herpesviruses

in humans, and their results are pretty intriguing.

They think that, in order for herpes to get from that ancestral chimp to us, it must have

involved at least one, and maybe more than one, of our extinct cousins.

To try to figure out how and when all this happened, they started with the modern viruses

In 2014, a group of researchers looked at the family tree of primate herpes and came

up with 10 scenarios that could explain the relationship between the two human viruses

All 10 of these scenarios were pretty simple and required just one of two possible events:

either a single transmission event between different species, or one instance of the

ancestral virus splitting into two lineages within the same host.

So, to test these scenarios, they used a new computational method that combined different

models of evolution, selection, and molecular clock dating.

And, the scenario that best fit the dates for when each herpesvirus split off from its

ancestor was that HSV1 - human oral herpes - and chimp herpes diverged around 6 million

years ago, which is around the time we shared our last common ancestor with chimps.

So it seems that we didn't get infected with the oral herpes virus from some chimp

ancestor -- instead, we inherited it, from an ancestor we share with chimps.

Which means the oral herpes virus has always been specific to our lineage.

That's not the case for the virus that causes genital herpes!

HSV2 seems to have split from the chimp virus much more recently, between 3 million and

And these researchers think it happened by jumping from a proto-chimp into an extinct

So, that study gives us a when and a where for the origin of human genital herpes - sometime

in the late Pliocene or early Pleistocene Epoch.

But if you've ever watched any of our videos on human evolution, you know that this was

a pretty crowded time for hominins in Africa.

Lots of our relatives were around then, possibly interacting with proto-chimps and with each

other, and developing all sorts of interesting behaviors, like maybe hunting and scavenging.

So, with this in mind, in 2017, another group of scientists picked up where the first group

They wanted to figure out which of those hominins was most likely the one that got infected

with chimp herpes, and passed it down to us as genital herpes, today.

This group started by gathering data on extinct hominins in Africa: where they were found

But they couldn't do the same for chimpanzees, because there are no chimp fossils from before

So, instead they used the modern ranges of chimps and bonobos, combined with data on

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The Two Viruses That We’ve Had For Millions of Years

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