Name: 28. Metal Ion Homeostasis 4
Uploaded: 2020-03-29T16:34:13.000Z
Duration: 51 min 56 s
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about iron metabolism in general in the first lecture.

to be iron metabolism and bacteria with a focus on hemes.

And the two things you want to talk about in the lecture today

are, how does iron get taken up into cells in humans,

with a focus on receptor mediated endocytosis,

and then we're going to start talking about hopefully iron

So in the last lecture, we introduced you

to some key features about iron chemistry

in general that we're going to use throughout this lecture

So you need to go back and review your notes

Or hopefully you've had it somewhere before,

and it's a review from you from freshman chemistry

And so iron metabolism-- what do we know?

We know the average human being has 3 to 4 grams of iron.

We talked about this at the end of the last class,

We all went through that most of our iron

is in our red blood cells in the form of hemoglobin.

But it's also-- so in the form of hemoglobin,

it also can be stored in proteins called ferritins,

which we're not going to spend much time on,

And then many of you may know that red blood

And we'll see that the iron is really continually recycled,

and we'll talk a little bit about the mechanism

So instead of excreting it, what happens is you recycle.

The iron unit's recycled by macrophages in the spleen.

And so the other place you see a fair amount of iron

And the third place you see a fair amount of iron

is in the tissues, because myoglobin, again,

has to deliver oxygen to the respiratory chain.

going to go back and forth between the PowerPoint

And so some things I'm going to write down some things not.

Hopefully you have these cartoons in front of you

that I will say here, and say it again and say it again.

And most of these big pictures have some issues with them.

But I think it still gives you the big picture.

So here's a duodenum, where we can take up iron from the diet.

And we'll talk about this in more detail,

but a key player in allowing the iron from the diet

to go into our system is going to be FPN--

But you're going to see FPN over and over again.

It allows iron to be transferred in the plus 2 state,

And so what we see, that if you look at iron from the diet,

[AUDIO OUT] somebody's guess as to how much there is.

And the question is, where does it go in the bloodstream?

going to talk about that's a carrier for iron in the plus 3

So we're going to see plus 2, plus 3 into conversions

has evolved to be able to deal with these different oxidation

We'll see that this little protein, TF, is transferrin,

for a-- very briefly, but it binds iron 3 and bicarbonate,

And marrow, which is-- accounts for approximately,

by mass, 4% of the body weight, makes all of our red and white

the heme for the erythrocytes makes the erythrocytes,

and the erythrocytes are the red blood cells

So out of the 4 grams, you have 2 and 1/2 grams of hemoglobin.

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28. Metal Ion Homeostasis 4

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