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  • How do painkillers work?

  • They act like a sponge and absorb the pain.

  • No.

  • When something is causing us damage, such as tip of a needle or pencil.

  • Special cells called nociceptors send signals to the brain.

  • The brain then perceives it as pain.

  • However, when cells of our body are severely damaged or injured, they release chemicals like arachidonic acid.

  • Now, just like a key fits in a lock, the arachidonic acid fits perfectly in enzymes called COX-1 and COX-2.

  • Forming prostaglandin and other compounds.

  • These compounds increase the sensitivity of nociceptors due to which it pains or hurts more.

  • Now, the most common painkillers are aspirin and ibuprofen.

  • These painkillers work by attaching themselves to COX-1 and COX-2.

  • Thus blocking them and not allowing arachidonic acid to bind to them.

  • As a result, prostaglandin is not produced and the sensitivity of nociceptors decreases.

  • Hence, the pain begins to subside.

How do painkillers work?

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