Name: "What is Apoptosis?" The Apoptotic Pathways and the Caspase Cascade
Uploaded: 2018-02-28T15:43:30.000Z
Duration: 3 min 59 s
Description: Thousands of YouTube videos with English-Chinese subtitles! Now you can learn to understand native speakers, expand your vocabulary, and improve your pronunciation...

Apoptosis is an important cellular process

that allows cells to die in a programmed fashion.

where the fetal hand starts out as webbed,

and fingers are formed through the programmed death

For example, pathological apoptosis may be induced

if cellular DNA is damaged beyond repair.

In apoptosis, the cell is broken down from within

these caspases first need to be activated.

called the extrinsic and intrinsic pathways.

The first pathway is referred to as the extrinsic pathway

because the initial signal comes from outside the cell.

This pathway is often initiated by other cells,

These lymphocytes have a surface molecule

This sets off a chain of intracellular events

that will ultimately result in apoptosis.

by a Fas Associated Death Domain or FADD.

In the final step of the extrinsic pathway,

begin the breakdown of cellular materials.

The caspase cascade acts as a common end-point

or if it stops receiving survival signals,

to punch a series  of channels in mitochondria,

For instance, cancer cells survive and replicate

because they are able to block apoptosis.

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"What is Apoptosis?" The Apoptotic Pathways and the Caspase Cascade

ultimately

process

essential

immune