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So I recently took one of those at-home DNA ancestry tests.
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All I had to do was fill up a vial with a disgusting amount of spit and mail it off for analysis.
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We're gonna be here for a very long time.
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I just spit it back up in my nose.
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A couple weeks later, this is what I got: It's a neat little pie chart with these specific
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percentages that were color-matched to different regions on a world map.
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The report told me I was mostly Southwest Asian — no surprises there, considering both
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my parents are from Iran.
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That percentage — 86.7% — I understood that to be the portion of my DNA that's
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West Asian.
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But it turns out, that's not exactly what ancestry tests are telling us at all.
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This is an ad for one DNA ancestry test, 23 and Me.
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An ethnically ambiguous woman travels the world, and a circle animates around her, sort
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of like the pie chart in my test results, as if to say, this woman's DNA is 29
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And here's an ad for a different ancestry test.
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“52% of my DNA comes from Scotland and Ireland.”
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And somehow this information compels him to... wear a kilt?
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Alright, so what are ancestry tests really telling us?
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Can you help me understand what my results
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are telling me?
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Because I'm getting mixed messages from ads and how other people talk about their results.
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This is Wendy Roth. I'm an associate professor of Sociology at the University of
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British Columbia.
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OK.
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First of all, these test results are not about your entire DNA.
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They're about a tiny, tiny fraction of your DNA.
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To understand how genetic ancestry tests work, let's start with the DNA itself.
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There are about 3 billion base pairs in our genetic code.
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Those are the As, Cs, Ts, and Gs that form the instructions that make us… us.
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Of these 3 billion base pairs, 99.9% are exactly the same in all humans.
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But for the remaining .1%, one person might have an adenine where another person has a guanine.
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These single-letter differences are called Single-Nucleotide Polymorphisms or SNPs.
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Groups of SNPs can help explain why some people are taller than others or why some people
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have green eyes while others have brown eyes.
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But most SNPs have no known effect at all.
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What many DNA tests are looking at are a relatively small number of SNPs, specific positions in
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this .1% in our DNA, in order to give you your results.
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When a testing company receives your sample, they
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compare your pattern of SNPs to different reference populations in their database.
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These reference populations contain SNPs known to exist more frequently in different modern
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populations in the world.
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Then the testing company will give you a percentage that represents
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how strongly your pattern of SNPs resembles that group.
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But this process has a bunch of important limitations and this is where things get complicated.
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Lots of markers are found in multiple populations around the world.
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First, even trying to classify humans into
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groups in the first place is tricky.
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Human genetic diversity isn't organized neatly into groups like countries or continents.
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Take a look at the distribution of this SNP that affects how a person absorbs folic acid.
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It's commonly found in Mexico, but also in Chile, or even China, just as often.
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So let's say that a particular marker is found in the South Asian population 30 percent
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of the time. There's still a possibility that when you inherited this marker you got
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it not from somebody who was South Asian, but from somebody who was in some completely different
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group that also happened to have that marker.
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Second, testing companies put together their reference populations based on academic research
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and other people that have taken genetic ancestry tests.
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And most testing companies aren't clear about how many people are represented in their
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reference populations.
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So each company might have different reference databases, which helps explain why you might
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get different results from different companies.
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So what does this all mean for my results?
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This is a probability with a margin of error.
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So it's not that you overall are eighty-five percent West Asian, but that
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the particular spot that they happened to look at, eighty-five percent of those locations are
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associated with Western Asia in their reference population.
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So what about these other results?
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Am I really 2 percent African?
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You've got a lot of, you know, sort of small trace percentages here.
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Percentages that small are really not meaningful, again because that could be affected by having
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one person in the database.
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And if that one person gets reclassified later on because they get a larger sample, that
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percentage will disappear.
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Ultimately, DNA ancestry tests are really just giving us a probability, the testing
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company's best guess.
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And that uncertainty isn't made very clear in the results.
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Buried in my results I found this “confidence slider.”
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It turns out, my results were presented at about 50% confidence by default.
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When I increased it to 90%, my results got much more vague.
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All of a sudden I was "broadly" West Asian and
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a lot of my genetic markers were unassigned.
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So, DNA ancestry tests don't actually tell us where our ancestors lived - they're really
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just giving us probabilities of where we're likely to have relatives today.
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But so what if people misinterpret their results?
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Well that has consequences.
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They can make us believe that our ethnicities have these bright-line distinctions between
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them, like in a pie chart.
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When people are presented with test results and these percentage breakdowns
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and they are led to think that these tests can tell you your race or they can tell you
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who you are, that that leads to a way of thinking — makes us feel that there are very stark
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and clear biological differences between races.
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One study found that DNA ancestry tests reinvigorate age-old beliefs in essential racial differences,
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that our socially constructed racial categories like “white” or “black” are essentially
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different from each other.
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Some groups have even turned to genetic ancestry tests to try and prove their “racial purity."
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DNA ancestry tests can be useful.
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Search YouTube and you'll find hundreds of stories of people using them to find lost
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relatives and fill in their family histories.
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And, to people who don't know a lot about
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their ancestry, the tests offer the best available estimate.
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But it's important to remember that, despite their marketing, these tests are just a company's
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best guess at matching your genetic markers to different parts of the world.
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What they're not going to tell you is whether you should wear a kilt or not.
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DNA ancestry tests might not be as informative as you want them to be,
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but more and more people are still taking them.
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And this giant database of genetic information is becoming super valuable to an unexpected group:
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Law enforcement.
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We've teamed up with Verge Science, to look into how your privacy is
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at risk because of genetic ancestry tests, even if you've never taken one.