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Every human being starts out the same way:
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two cells,
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one from each parent,
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found each other and became one.
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And that one cell reproduced itself,
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dividing,
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and dividing,
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and dividing
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until there were 10 trillion of them.
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Do you realize there are more cells in one persons body
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than there are stars in the Milky Way?
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But those 10 trillion cells are not just sitting there in a big pile.
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That would make for a pretty boring human being!
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So what is it that says a nose is a nose,
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and toes is toes?
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What is it that says this is bone,
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and this is brain,
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and this is heart,
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and this is that little thing in the back of your throat
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that you can never remember the name of?
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Everything that you are or ever will be made of
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starts as a tiny link of instructions
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found in each and every cell.
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Every time your body wants to make something,
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it goes back to the instruction book,
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looks it up, and puts it together.
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So how does one cell hold all that information?
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Let's get small.
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I mean, really small,
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smaller than the tip of a sewing needle.
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Then we can take a journey inside a single cell
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to find out what makes up the book of you,
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your genome.
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The first thing we see is that the whole genome,
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all your DNA,
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is contained inside its own tiny compartment
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called the nucleus.
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If we stretched out all the DNA in this one cell
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into a single thread,
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it would be over 3 feet long!
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We have to make it fit in a tiny compartment
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that is a million times smaller.
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We could just bunch it up like Christmas lights,
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but that can get messy.
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We need some organization.
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First, the long thread of DNA wraps around proteins
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clustered into little beads called nucleosomes,
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which end up looking like a long, beaded necklace.
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And that necklace is wrapped up in its own spiral
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like an old telephone cord.
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And those spirals get layered on top of one another
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until we get a neat little shape that fits inside the nucleus.
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Waaah! Three feet of DNA squeezed into a tiny compartment.
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If only we could hire DNA to pack our suitcases!
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Each tiny mass of DNA is called a chromosome.
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The book of you would have 46 chapters,
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one for each chromosome.
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23 chapters of your book came from your mom,
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and 23 chapters came from your dad.
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Two of those chapters, called "X" and "Y",
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determine if you are male, "XY",
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or female, "XX".
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Put them together and we get two almost identical
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but slightly different sets of 23 chapters.
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The tiny variations are what makes each person different.
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It's estimated that all the chapters together
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hold about 20,000 individual instructions, called genes.
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Written out, all those 20,000 instructions
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are 30 million letters long!
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If someone were writing one letter per second,
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it would take them almost an entire year to write it once.
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It turns out that our genome book is much, much longer
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than just those 30 million letters,
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almost 100 times longer!
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What are all those extra pages for?
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Well, each page of instructions has a few pages of nonsense inserted
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that have to be taken out before we end up with something useful.
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The parts we throw out, we call introns.
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The instructions we keep, we call exons.
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We can also have hundreds of pages in between each gene.
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Some of these excess pages were inserted
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by nasty little infections in our ancestors,
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but some of them are actually helpful.
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They protect the ends of each chapter from being damaged,
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or some help our cells find a particular thing they are looking for,
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or give a cell a signal to stop making something.
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All in all, for every page of instructions
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there is almost 100 pages of filler.
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In the end, each of our books' 46 chapters
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is between 48 and 250 million letters long.
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That's 3.2 billion letters total!
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To type all that copy, you would be at it for over 100 years,
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and the book would be over 600,000 pages long.
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Every type of cell carries the same book,
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but each has a set of bookmarks that tell it exactly
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which pages it needs to look up.
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So a bone cell reads only the set of instructions it needs to become bone.
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Your brain cells,
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they read the set that tells them how to become brain.
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If some cells suddenly decide to start reading other instructions,
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they can actually change from one type to another.
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So every little cell in your body is holding on to an amazing book,
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full of the instructions for life.
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Your nose reads nose pages,
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your toes read toes pages,
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and that little thing in the back of your throat,
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it's got its own pages too.
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They are under uvula.