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Is there a disease that makes us love cats,
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and do you have it?
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Maybe,
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and it's more likely than you'd think.
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We're talking about toxoplasmosis,
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a disease caused by toxoplasma gondii.
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Like all parasites, toxoplasma lives at the expense of its host,
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and needs its host to produce offspring.
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To do that, toxo orchestrates a brain manipulation scheme
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involving cats,
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their rodent prey,
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and virtually all other birds and mammals,
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including humans.
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Documented human infections go as far back as ancient Egypt.
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We found samples in mummies.
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Today, about a third of the world's population is infected,
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and most of them never even know it.
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In healthy people, symptoms often don't show up at all.
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When they do, they're mild and flu-like.
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But those are just the physical symptoms.
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Toxoplasma also nestles into our brains
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and meddles with our behavior behind the scenes.
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To understand why, let's take a look at the parasite's life cycle.
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While the parasite can multiply in practically any host,
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it can only reproduce sexually in the intestines of cats.
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The offspring, called oocysts, are shed in the cat's feces.
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A single cat can shed up to a hundred million oocysts.
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If another animal, like a mouse, accidentally ingests them,
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they'll invade the mouse's tissues and mature to form tissue cysts.
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If the mouse gets eaten by a cat,
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the tissue cysts become active and release offspring
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that mate to form new oocysts,
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completing the cycle.
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But there's a problem.
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A mouse's natural desire to avoid a cat makes it tough to close this loop.
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Toxoplasma has a solution for that.
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The parasites invade white blood cells to hitch a ride to the brain
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where they seem to override the innate fear of predators.
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Infected rodents are more reckless and have slower reaction times.
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Strangest of all, they're actually attracted to feline urine,
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which probably makes them more likely to cross paths with a cat
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and help the parasite complete its life cycle.
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How does the parasite pull this off?
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Although the exact mechanism isn't known, toxo appears to increase dopamine,
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a brain neurotransmitter that is involved in novelty-seeking behavior.
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Thus, one idea is that toxo tinkers with neurotransmitters,
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the chemical signals that modulate emotions.
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The result?
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Fatal attraction.
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But mice aren't the only animals that end up with these parasites,
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and that's where humans, and all of toxo's other hosts, come in.
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We can accidentally ingest oocysts in contaminated water,
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or unwashed produce,
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or from playing in sandboxes,
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or cleaning out litter boxes.
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This is behind the common recommendation that pregnant women not change cat litter.
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Toxo can cause serious birth defects.
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We can also get toxo from eating undercooked meat
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from other animals that picked up some oocysts.
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And it turns out that toxo can mess with our brains, too.
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Studies have found connections between toxo and schizophrenia,
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bipolar disorder,
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obsessive compulsive disorder,
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and aggression.
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It also slows reactions and decreases concentration,
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which may be why one study found that people involved in traffic accidents
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were almost three times more likely to have toxoplasma.
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So is toxo manipulating our brains as an evolutionary strategy
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to get predatory cats to eat us?
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Or are our brains just similar enough to a rodent's
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that the same neurological tricks that lure them in catch us in the net, too?
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And is toxo the reason so many people love cats and keep them as pets?
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Well, the jury's still out on that one.
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Some recent studies even contradict the idea.
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Regardless, toxoplasma has definitely benefitted from humans
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to become one of the world's most successful parasites.
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It's not just our willingness to let cats on our dining room tables
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or in our beds.
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Raising livestock and building cities which attract rodents
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has provided billions of new hosts,
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and you and your cat may be two of them.