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Imagine something small enough to float on a particle of dust
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that holds the keys to understanding cancer, virology, and genetics.
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Luckily for us,
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such a thing exists in the form of trillions upon trillions
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of human lab-grown cells called HeLa.
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Let's take a step back for a second.
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Scientists grow human cells in the lab to study how they function,
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understand how diseases develop,
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and test new treatments without endangering patients.
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To make sure that they can repeat these experiments over and over,
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and compare the results with other scientists,
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they need huge populations of identical cells
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that can duplicate themselves faithfully for years,
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but until 1951, all human cell lines that researchers tried to grow
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had died after a few days.
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Then a John Hopkins scientist named George Gey
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received a sample of a strange looking tumor:
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dark purple, shiny, jelly-like.
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This sample was special.
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Some of its cells just kept dividing,
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and dividing,
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and dividing.
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When individual cells died,
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generations of copies took their place and thrived.
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The result was an endless source of identical cells that's still around today.
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The very first immortal human cell line.
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Gey labeled it "HeLa" after the patient with the unusual tumor, Henrietta Lacks.
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Born on a tobacco farm in Virginia,
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she lived in Baltimore with her husband and five children.
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She died of aggressive cervical cancer
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a few months after her tumorous cells were harvested,
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and she never knew about them.
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So what's so special about the cells from Henrietta Lacks
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that lets them survive when other cell lines die?
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The short answer is we don't entirely know.
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Normal human cells have built-in control mechanisms.
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They can divide about 50 times before they self destruct
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in a process called apoptosis.
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This prevents the propagation of genetic errors
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that creep in after repeated rounds of division.
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But cancer cells ignore these signals, dividing indefinitely
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and crowding out normal cells.
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Still, most cell lines eventually die off, especially outside the human body.
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Not HeLa, though, and that's the part we can't yet explain.
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Regardless, when Dr. Gey realized he had the first immortal line of human cells,
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he sent samples to labs all over the world.
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Soon the world's first cell production facility
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was churning out 6 trillion HeLa cells a week,
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and scientists put them to work in an ethically problematic way,
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building careers and fortunes off of Henrietta's cells
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without her or her family's consent, or even knowledge until decades later.
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The polio epidemic was at its peak in the early 50s.
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HeLa cells, which easily took up and replicated the virus,
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allowed Jonas Salk to test his vaccine.
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They've been used to study diseases,
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including measles,
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mumps,
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HIV,
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and ebola.
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We know that human cells have 46 chromosomes
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because a scientist working with HeLa discovered a chemcial
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that makes chromosomes visible.
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HeLa cells themselves actually have around 80 highly mutated chromosomes.
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HeLa cells were the first to be cloned.
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They've traveled to outer space.
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Telomerase,
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an enzyme that helps cancer cells evade destruction by repairing their DNA,
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was discovered first in HeLa cells.
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In an interesting turn of fate,
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thanks to HeLa, we know that cervical cancer can be caused by a virus called HPV
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and now there's a vaccine.
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HeLa-fueled discoveries have filled thousands of scientific papers,
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and that number is probably even higher than anyone knows.
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HeLa cells are so resilient that they can travel on almost any surface:
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a lab worker's hand,
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a piece of dust,
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invading cultures of other cells and taking over like weeds,
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countless cures, patents and discoveries all made thanks to Henrieta Lacks.