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  • Ow ow ow

  • DAng

  • I mean THANK YOU BODY.

  • Hey guys julia here for DNews

  • Pain helps us navigate the world.

  • Pain tells us when something is hot so we don't burn ourselves.

  • Pain tells us when we're hurt so we don't damage our bodies further.

  • As annoying and uncomfortable as it is, it actually saves us.

  • Pain protects us from harm.

  • But not everyone is so...lucky.

  • Some people are born with a genetic mutation that leaves them unable to feel pain.

  • There's actually a few mutations that lead to the condition called congenital insensitivity

  • to pain.

  • One mutation occurs in the PRDM12 gene.

  • According to a study published in the journal Nature Genetics, this mutation leads to a

  • malformation of nerve cells or neurons.

  • Without functioning nerves, there's nothing to detect a painful experience.

  • Another mutation that causes people to not feel pain occurs in the SCN9A gene.

  • It causes disruptions not in the nerves, but in the way nerves talk to each other.

  • Nerve cells communicate by sodium ions, as these ions get passed through channels from

  • one nerve cell to the next, the pain signal travels from the injury site where it's felt,

  • up the spinal cord and into the brain.

  • But a mutation in the SCN9A gene stops these channels, called Nav1.7 channels, from forming.

  • Without these channels, pain messages can't be sent.

  • So scientists being scientists, made mice with this mutation in a study published in

  • the journal Nature Communications!

  • And not surprisingly, the mice couldn't feel pain.

  • When their tails were exposed to extreme heat or cold, they showed no response.

  • But surprisingly, even though they felt no pain, their body tried to soothe it.

  • The mutated mice showed high levels of enkephalins, a type of opioid, the brain's natural painkiller

  • at the site of injury.

  • So even though these mice couldn't feel pain, their bodies recognized that pain and

  • tried to make the mice feel better.

  • So the researchers thought, hey, people who have less opioids in them tend to feel more

  • pain, I wonder what would happen if people who don't feel pain had less of these soothing

  • opioids.

  • So they gave a woman who cannot feel pain naloxone, a medication typically used to treat

  • opioid drug overdose, and shot her with a heated laser.

  • The drug stopped her opioid production.

  • And voila!

  • She felt pain!

  • Scientists said that the womanquite enjoyedthe sensation.

  • So cool right? but uh, what good is it making people feel pain?

  • Whether we like it or not, pain evolved to save us.

  • Just take a look at our nerves that transmit pain.

  • Nociceptors sensory receptors are nerves whose only job is to transmit pain from the point

  • of injury to the brain.

  • And they are fast, like pain can make it's way through these cells in 5–30 milliseconds

  • or about about one meter per second.

  • It's so quick and uncomfortable, because it gets you away from whatever is causing

  • the pain super fast.

  • Some evolutionary biologists think that a lesser warning, more of a “red flagwouldn't

  • be enough for us to react so suddenly and strongly against a potential danger.

  • And we do know what happens when we don't have these kind of alarm bells in our body.

  • According to a study published in the Journal of Clinical Investigation, those who are born

  • without the ability to feel pain often suffer from infections they don't realize they

  • have, self injury, and they have shorter lives!

  • So the next time you stub your toe, don't yell out an expletive, yell outthank you!”

  • it's saving your life.

  • Humans.. well we let each other know when we feel pain.

  • When other animals feel pain they yelp or cry out in some way.

  • But since crabs and other invertebrates can't… we kind of just assumed they don't feel

  • pain.

  • Well put down that order of crab legs, crabs do feel pain.

  • To find out more, check out this episode, right here

Ow ow ow

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B2 US pain feel pain mutation injury study published opioid

Why Some People Don’t Feel Pain

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    joey joey posted on 2021/04/11
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