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Narrator: Did you know the condom
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is over 5,000 years old?
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That's right, some of the first forms of birth control
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date back to around 3,000 BC,
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and while the condom has made some strides
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since the Bronze Age, men still don't have
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a much better option all these millennia later.
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Besides a vasectomy.
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Especially compared to the pills,
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IUDs, and implants available to women today.
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So why don't we have birth control for men?
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In 2002, researchers asked
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more than 9,000 men across four continents
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whether they'd be willing to use contraception
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capable of preventing sperm production.
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Over half said yes.
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So the problem isn't lack of interest,
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it's partly human biology.
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Women ovulate just one or two eggs each month.
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Men, on the other hand, produce sperm daily,
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and it's not just one or two.
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There's literally hundreds of millions of sperm
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produced each day, so because there's so many
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sperm produced, actually, you can reduce your sperm number
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over 90% and still be completely fertile.
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Narrator: To reach infertility, a man's sperm count
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needs to be somewhere around 1 to 10 million
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per milliliter, but getting there is near impossible,
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at least without side effects.
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That's because sperm count is tied
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to the production of testosterone.
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In the past, researchers tried decreasing testosterone
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in an effort to decrease sperm count.
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The problem is you don't have any libido,
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you have very little testosterone to act on other tissues
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and so forth, and so the side effects were so dramatic
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that it really wasn't ever
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going to be a contraceptive pill.
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Narrator: Scientists also tried using different compounds
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that attack the cells that produce sperm.
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But again, biology got in the way.
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Germ cells, as they're called, developed inside
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a fortress-like structure within the testes.
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So literally, nothing can get through it.
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There's been a lot of small molecule studies
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to try and actually attack the germ cell
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to stop it from working.
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Literally, I can think of 10 or 15 different compounds
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that actually have been developed to do that,
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but they don't work because of that barrier.
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Narrator: But the complex male anatomy
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isn't the only problem. It's also funding or lack thereof.
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In 2002, two big pharmaceutical companies
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took interest in male contraception, Schering and Organon.
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And together they funded a large clinical trial
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on a hormone-based contraceptive,
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offering hope that a pill backed by Big Pharma
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might be on the horizon.
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Then these two companies became, as you know,
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acquired by bigger company, and then even bigger company,
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so now they are merged in huge companies,
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and women's health is still a priority
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in many of the companies,
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but men's health became part
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of the general matter of health.
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And therefore, the development of contraception
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becomes a really very low priority.
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Narrator: According to Dr. Wang,
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male contraception was also too risky
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for Big Pharma at the time.
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The long-term side effects were unknown.
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Companies were concerned that women might not trust it,
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and despite the survey results, it was unclear whether men
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would actually use a hormone-based contraception.
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Today, the limited funding comes mostly from
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government agencies like the National Institutes of Health.
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But there are in fact some promising lines of research.
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Dr. Wang is working on a gel that can lower testosterone
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where it matters, in the testes where sperm is produced,
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while keeping testosterone levels normal elsewhere.
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That means low sperm count and, more importantly,
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no major side effects.
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We have preliminary studies to show
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that if we give the gel and if the man applies the gel,
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90% of the men will reach the level that you talk about,
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1 million per mil.
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And Skinner is pursuing a new approach,
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shutting down Sertoli cells,
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which are a part of that impenetrable barrier
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that houses germ cells.
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So if you shut down the Sertoli cell,
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then you shut down the sperm production.
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Narrator: But perhaps most promising
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is a sort of reversible vasectomy that's in the works.
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So they have this ability to inject this gel
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into what's called the vas deferens,
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and it makes this plug, so then essentially
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it does the same thing, but you're not cutting it.
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Then believe it or not, you can actually
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inject this chemical mixture, which will dissolve the plug,
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and so then you can get your fertility back.
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Narrator: But as promising as these approaches may be,
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they're still years, if not decades, out, Skinner says.
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And without more funding, some of them
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may never hit the market.
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So at least for now, men are left with few options.
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Irreversible vasectomies, pulling out ,
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and that slightly updated Bronze Age invention.